A feedforward loop of NLRC5 (de)ubiquitination keeps IKK-NF-κB in check

J Cell Biol. 2015 Dec 7;211(5):941-3. doi: 10.1083/jcb.201511039. Epub 2015 Nov 30.

Abstract

Many receptors signal via adaptors to the IKK-NF-κB axis, transducing extracellular cues to transcriptional regulation. In this issue, Meng et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505091) reveal that the IKK regulator NLRC5 shapes NF-κB activity through a feedforward loop of NLRC5 ubiquitination and deubiquitination, highlighting a new pathway modulating IKK-NF-κB activity.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Intracellular Signaling Peptides and Proteins / chemistry*
  • NF-kappa B p50 Subunit / metabolism*
  • Ubiquitin / chemistry*

Substances

  • Intracellular Signaling Peptides and Proteins
  • NF-kappa B p50 Subunit
  • Ubiquitin