Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines

Cell Death Dis. 2015 Dec 31;6(12):e2028. doi: 10.1038/cddis.2015.379.

Authors

A A Mahbub¹, C L Le Maitre¹, S L Haywood-Small¹, N A Cross¹, N Jordan-Mahy¹

Affiliation

¹ Biomolecular Sciences Research Centre, The Department of Biosciences and Chemistry, Faculty of Health and Wellbeing, Sheffield Hallam University, Howard Street, Sheffield, South Yorkshire S1 1WB, UK.

No abstract available

Publication types

News

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / pharmacology*
Cell Line, Tumor
Doxorubicin / administration & dosage
Doxorubicin / pharmacology*
Drug Synergism
Etoposide / administration & dosage
Etoposide / pharmacology*
Glutathione / metabolism*
Humans
Jurkat Cells
Leukemia, Lymphoid / drug therapy
Leukemia, Lymphoid / metabolism*
Leukemia, Myeloid / drug therapy*
Leukemia, Myeloid / metabolism
Polyphenols / administration & dosage
Polyphenols / pharmacology*
Topoisomerase II Inhibitors / administration & dosage
Topoisomerase II Inhibitors / pharmacology

Substances

Polyphenols
Topoisomerase II Inhibitors
Etoposide
Doxorubicin
Glutathione