Lipid droplets go nuclear

Robert V Farese Jr; Tobias C Walther

doi:10.1083/jcb.201512056

Lipid droplets go nuclear

J Cell Biol. 2016 Jan 4;212(1):7-8. doi: 10.1083/jcb.201512056.

Authors

Robert V Farese Jr¹, Tobias C Walther²

Affiliations

¹ Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115 Department of Cell Biology, Harvard Medical School, Harvard University, Boston, MA 02115 Broad Institute of MIT and Harvard, Cambridge, MA 02142 twalther@hsph.harvard.edu robert@hsph.harvard.edu.
² Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115 Department of Cell Biology, Harvard Medical School, Harvard University, Boston, MA 02115 Howard Hughes Medical Institute, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115 Broad Institute of MIT and Harvard, Cambridge, MA 02142 twalther@hsph.harvard.edu robert@hsph.harvard.edu.

Abstract

Lipid droplets (LDs) are sometimes found in the nucleus of some cells. In this issue, Ohsaki et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507122) show that the nuclear membrane, promyelocytic leukemia bodies, and the protein PML-II play a role in nuclear LD formation, suggesting functional relationships between these structures.

Publication types

Comment

MeSH terms

Animals
Cell Nucleus / metabolism*
Female
Humans
Lipid Droplets / metabolism*
Nuclear Proteins / metabolism*
Transcription Factors / metabolism*
Tumor Suppressor Proteins / metabolism*

Substances

Nuclear Proteins
Transcription Factors
Tumor Suppressor Proteins