Interplay of autophagy and apoptosis during PRRSV infection of Marc145 cell

Infect Genet Evol. 2016 Apr:39:51-54. doi: 10.1016/j.meegid.2016.01.011. Epub 2016 Jan 13.

Abstract

Autophagy and apoptosis play essential roles 'in virus infection. Our study was performed to investigate the interplay between autophagy and apoptosis in PRRSV replication. In our present study, autophagy and apoptosis were induced by PRRSV infection. Viral replication was dampened/attenuated by autophagy deficient and potentiated by apoptosis inhibition. Furthermore, PRRSV replication was restored by apoptosis inhibition in autophagy deficient cells. Taken together, our findings unveil the functional relationship between autophagy and apoptosis during PRRSV replication.

Keywords: Apoptosis; Autophagy; Marc145 cell; PRRSV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Autophagy
  • Autophagy-Related Protein 5 / genetics*
  • Autophagy-Related Protein 5 / metabolism
  • Caspase 3 / genetics*
  • Caspase 3 / metabolism
  • Cell Line
  • Gene Expression Regulation
  • Host-Pathogen Interactions
  • Poly(ADP-ribose) Polymerases / genetics*
  • Poly(ADP-ribose) Polymerases / metabolism
  • Porcine Reproductive and Respiratory Syndrome / virology*
  • Porcine respiratory and reproductive syndrome virus / physiology*
  • RNA Interference
  • Swine
  • Virus Replication*

Substances

  • Autophagy-Related Protein 5
  • Poly(ADP-ribose) Polymerases
  • Caspase 3