Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats

Mol Nutr Food Res. 2016 May;60(5):981-91. doi: 10.1002/mnfr.201500761. Epub 2016 Feb 23.

Abstract

There are reports of positive effects of quercetin on cardiovascular pathologies, however, mainly due to its low biovailability, the mechanism remains elusive. Here, we report that one metabolite formed by human microflora (3-(3-hydroxyphenyl)propionic acid)relaxed isolated rat aorta and decreased arterial blood pressure in rats.

Keywords: Blood pressure; Flavonoid; Metabolite; Phenolic; Quercetin; Rat; Vascular.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arterial Pressure / drug effects*
  • Chromatography, High Pressure Liquid
  • Flavonoids / pharmacology*
  • Gastrointestinal Microbiome
  • Hemodynamics
  • Humans
  • In Vitro Techniques
  • Linear Models
  • Male
  • Phenols / pharmacology*
  • Propionates / pharmacology*
  • Rats
  • Rats, Inbred SHR
  • Rats, Wistar
  • Tandem Mass Spectrometry

Substances

  • 3-hydroxyphenylpropionic acid
  • Flavonoids
  • Phenols
  • Propionates