Two-component signal transduction system SaeRS is involved in competence and penicillin susceptibility in Staphylococcus epidermidis

J Basic Microbiol. 2016 Apr;56(4):358-68. doi: 10.1002/jobm.201500488. Epub 2016 Feb 22.

Abstract

Staphylococcus epidermidis, which is a causative pathogen of nosocomial infection, expresses its virulent traits such as biofilm and autolysis regulated by two-component signal transduction system SaeRS. In this study, the S. epidermidis SaeRS was identified to negatively regulate the expression of genes involved in competence (comF, murF), cytolysis (lrgA), and autolysis (lytS) by DNA microarray or real-time RT-PCR analysis. In addition, saeRS mutant showed increased competence and higher susceptibility to antibiotics such as penicillin and oxacillin than the wild-type strain. The study will be helpful for understanding the characterization of the SaeRS in S. epidermidis.

Keywords: Competence; Penicillin susceptibility; SaeRS; Staphylococcus epidermidis; Two-component signal transduction system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / drug effects
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism*
  • Biofilms / drug effects
  • DNA, Bacterial / genetics
  • Gene Expression Regulation, Bacterial
  • Microbial Sensitivity Tests
  • Oxacillin / pharmacology
  • Penicillin G / pharmacology*
  • Signal Transduction
  • Staphylococcus epidermidis / drug effects*
  • Staphylococcus epidermidis / genetics
  • Staphylococcus epidermidis / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • DNA, Bacterial
  • Penicillin G
  • Oxacillin