Abstract
Seven new compounds constituted by three secoiridoids (1-3), two isocoumarins (4 and 5), an iridoid (6), and an aromatic derivative (7) in addition to 24 known compounds were isolated from the stem bark of Fagraea fragrans. The structures of the new compounds were determined on the basis of spectroscopic data analysis. The isolated compounds showed no antibacterial activity against Staphylococcus aureus and Escherichia coli. However, 5-formylisochromen-1-one (4), (-)-mellein (8), and swermacrolactone C (9) exhibited potent antimycobacterial activities against Mycobacterium smegmatis when used in combination with the antibiotic drug erythromycin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Erythromycin / pharmacology*
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Iridoids / chemistry
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Iridoids / isolation & purification*
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Iridoids / pharmacology*
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Isocoumarins / chemistry
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Isocoumarins / isolation & purification*
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Isocoumarins / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Mycobacterium smegmatis / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry
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Staphylococcus aureus / drug effects
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Thailand
Substances
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5-formylisochromen-1-one
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Anti-Bacterial Agents
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Iridoids
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Isocoumarins
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fraganal
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Erythromycin