Abstract
The formation of tumor vasculature and cell invasion along white matter tracts have pivotal roles in the development and progression of glioma. A better understanding of the mechanisms of angiogenesis and invasion in glioma will aid the development of novel therapeutic strategies. The processes of angiogenesis and invasion cause the production of an array of adhesion molecules and extracellular matrix (ECM) components. This review focuses on the role of adhesion molecules and the ECM in malignant glioma. The results of clinical trials using drugs targeted against adhesion molecules and the ECM for glioma are also discussed.
Keywords:
Adhesion molecules; Angiogenesis; Extracellular matrix; Invasion; Malignant glioma.
MeSH terms
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Angiogenesis Inhibitors / pharmacology
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Angiogenesis Inhibitors / therapeutic use
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Antibodies / therapeutic use
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Brain Neoplasms / blood supply
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / genetics*
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Brain Neoplasms / pathology
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Cell Adhesion Molecules / genetics*
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Cell Adhesion Molecules / metabolism*
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Disease Progression
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Extracellular Matrix / genetics*
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Extracellular Matrix / metabolism*
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Glioma / blood supply
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Glioma / drug therapy*
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Glioma / genetics*
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Glioma / pathology
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Humans
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Molecular Targeted Therapy*
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Neoplasm Invasiveness / genetics
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Neovascularization, Pathologic / genetics
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Neovascularization, Pathologic / metabolism
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Snake Venoms / pharmacology
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Snake Venoms / therapeutic use
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Thalidomide / pharmacology
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Thalidomide / therapeutic use
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White Matter / blood supply
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White Matter / pathology
Substances
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Angiogenesis Inhibitors
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Antibodies
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Cell Adhesion Molecules
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Snake Venoms
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Cilengitide
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Thalidomide