Neuropathological basis of nonmotor manifestations of Parkinson's disease

Mov Disord. 2016 Aug;31(8):1114-9. doi: 10.1002/mds.26605. Epub 2016 Mar 31.

Abstract

Nonmotor manifestations of Parkinson's disease (PD) can begin well before motor PD begins. It is now clear, from clinical and autopsy studies, that there is significant Lewy-type α-synucleinopathy present outside the nigro-striatal pathway and that this may underlie these nonmotor manifestations. This review discusses neuropathological findings that may underlie nonmotor symptoms that either predate motor findings or occur as the disease progresses. © 2016 International Parkinson and Movement Disorder Society.

Keywords: Parkinson's disease; nonmotor signs; synuclein.

Publication types

  • Review

MeSH terms

  • Autonomic Nervous System Diseases* / etiology
  • Autonomic Nervous System Diseases* / pathology
  • Autonomic Nervous System Diseases* / physiopathology
  • Cognitive Dysfunction* / etiology
  • Cognitive Dysfunction* / pathology
  • Cognitive Dysfunction* / physiopathology
  • Humans
  • Lewy Body Disease* / etiology
  • Lewy Body Disease* / pathology
  • Lewy Body Disease* / physiopathology
  • Parkinson Disease* / complications
  • Parkinson Disease* / pathology
  • Parkinson Disease* / physiopathology
  • REM Sleep Behavior Disorder* / etiology
  • REM Sleep Behavior Disorder* / pathology
  • REM Sleep Behavior Disorder* / physiopathology