Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

Xiangqian Jia; Weizhi Wang; Qiuju Han; Zihua Wang; Yunhong Jia; Zhiyuan Hu

doi:10.1021/acsmedchemlett.6b00028

Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

ACS Med Chem Lett. 2016 Feb 10;7(4):429-34. doi: 10.1021/acsmedchemlett.6b00028. eCollection 2016 Apr 14.

Authors

Xiangqian Jia¹, Weizhi Wang², Qiuju Han¹, Zihua Wang², Yunhong Jia³, Zhiyuan Hu²

Affiliations

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China; Pharmacy College and College of Basic Science, Liaoning Medical University, Jinzhou, Liaoning 121001, China.
² CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, China.
³ Pharmacy College and College of Basic Science, Liaoning Medical University, Jinzhou, Liaoning 121001, China; Pharmacy College and College of Basic Science, Liaoning Medical University, Jinzhou, Liaoning 121001, China.

Abstract

We present here a specific targeting nanocarrier system by functionalization of liposomes with one new type of breast cancer targeting peptide (H6, YLFFVFER) by a micromixer with high efficiency. Antitumor drugs could be successfully delivered into human epidermal growth factor receptor 2 (HER2) positive breast cancer cells with high efficiency in both in vivo and ex vivo models.

Keywords: Antitumor; HER2; Nanocarrier; YLFFVFER.