Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations

Derek J Hausenloy; Hans Erik Botker; Thomas Engstrom; David Erlinge; Gerd Heusch; Borja Ibanez; Robert A Kloner; Michel Ovize; Derek M Yellon; David Garcia-Dorado

doi:10.1093/eurheartj/ehw145

Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations

Eur Heart J. 2017 Apr 1;38(13):935-941. doi: 10.1093/eurheartj/ehw145.

Authors

Derek J Hausenloy^{1

2

3

4}, Hans Erik Botker⁵, Thomas Engstrom⁶, David Erlinge⁷, Gerd Heusch⁸, Borja Ibanez^{9

10}, Robert A Kloner^{11

12}, Michel Ovize^{13

14}, Derek M Yellon^{3

4}, David Garcia-Dorado¹⁵

Affiliations

¹ Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
² National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore.
³ The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK.
⁴ National Institute of Health Research University College London Hospitals Biomedical Research Centre, London W1T 7DN, UK.
⁵ Department of Cardiology, Aarhus University Hospital Skejby, DK-8200 Aarhus N, Denmark.
⁶ Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
⁷ Department of Cardiology, Lund University, Lund, Sweden.
⁸ Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany.
⁹ Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
¹⁰ IIS-Fundación Jiménez Díaz Hospital, Madrid, Spain.
¹¹ Huntington Medical Research Institutes, Pasadena, CA, USA.
¹² Division of Cardiovascular Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
¹³ Explorations Fonctionnelles Cardiovasculaires, Hôpital Louis Pradel, Lyon, France.
¹⁴ UMR 1060 (CarMeN), Université Claude Bernard, Lyon, France.
¹⁵ Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine / therapeutic use
Cardiotonic Agents / therapeutic use
Clinical Trials as Topic / methods
Combined Modality Therapy
Coronary Vessels / physiology
Cyclosporine / therapeutic use
Enzyme Inhibitors / therapeutic use
Humans
Hypothermia, Induced / methods
Ischemic Postconditioning / methods
Metoprolol / therapeutic use
Mitochondrial Membrane Transport Proteins / physiology
Mitochondrial Permeability Transition Pore
Myocardial Reperfusion / adverse effects
Myocardial Reperfusion Injury / etiology
Myocardial Reperfusion Injury / prevention & control*
Nitric Oxide / metabolism
Nitric Oxide / therapeutic use
Nitrites / therapeutic use
Nucleotides, Cyclic / metabolism
Oligopeptides / therapeutic use
Oximes / therapeutic use
Patient Selection
Protein Kinase C / antagonists & inhibitors
ST Elevation Myocardial Infarction / complications*
ST Elevation Myocardial Infarction / etiology
ST Elevation Myocardial Infarction / therapy
Secosteroids / therapeutic use
Signal Transduction / physiology
Vasodilator Agents / therapeutic use

Substances

Cardiotonic Agents
Enzyme Inhibitors
Mitochondrial Membrane Transport Proteins
Mitochondrial Permeability Transition Pore
Nitrites
Nucleotides, Cyclic
Oligopeptides
Oximes
Secosteroids
Vasodilator Agents
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide
cyclic guanosine monophosphate-adenosine monophosphate
Nitric Oxide
3,5-seco-4-norcholestan-5-one oxime-3-ol
Cyclosporine
Protein Kinase C
Metoprolol
Adenosine