Tuning the reactivity of Sp1 zinc fingers with platinum complexes

Zhifeng Du; Raphael E F de Paiva; Yun Qu; Nicholas Farrell

doi:10.1039/c6dt01128d

Tuning the reactivity of Sp1 zinc fingers with platinum complexes

Dalton Trans. 2016 Jun 7;45(21):8712-6. doi: 10.1039/c6dt01128d. Epub 2016 May 12.

Authors

Zhifeng Du¹, Raphael E F de Paiva, Yun Qu, Nicholas Farrell

Affiliation

¹ Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284-2006, USA. npfarrell@vcu.edu.

PMID: 27171123
DOI: 10.1039/c6dt01128d

Abstract

cis-DDP presents reactivity towards the transcription factor Sp1-F3, as opposed to previous observations for Sp1-F2. Replacing the ammine ligands with the chelating ethylenediamine increases the reactivity giving a unique dinuclear {Pt(en)}2-bis(cysteine)-bridged product, confirmed by study of the binding sequence ACPECP.

MeSH terms

Amino Acid Sequence
Coordination Complexes / chemistry*
Coordination Complexes / metabolism
Humans
Isomerism
Magnetic Resonance Spectroscopy
Mass Spectrometry
Platinum / chemistry*
Protein Binding
Sp1 Transcription Factor / chemistry*
Sp1 Transcription Factor / metabolism
Zinc Fingers

Substances

Coordination Complexes
Sp1 Transcription Factor
SP1 protein, human
Platinum