Hepatoprotective pyranocoumarins from the stems of Clausena emarginata

Phytochemistry. 2016 Oct:130:238-43. doi: 10.1016/j.phytochem.2016.05.010. Epub 2016 Jun 8.

Abstract

Seven pyranocoumarins, clauemarmarins A-G, along with 6 known analogues were isolated from the stems of Clausena emarginata. Their structures were elucidated by extensive spectroscopic analyses, and the absolute stereochemistries at C-6″ of clauemarmarin B, C and D and the absolute configurations of clauemarmarin E, F and G were determined by ECD experiments. Compounds clauemarmarin C, D and two known analogues exhibited hepatoprotective activities against DL-galactosamine-induced damage in WB-F344 cells at the concentration of 10 μM.

Keywords: Clauemarmarins A−G; Clausena emarginata; Hepatoprotective activity; Pyranocoumarins; Rutaceae.

MeSH terms

  • Alkaloids / chemistry
  • Clausena / chemistry*
  • Galactosamine / pharmacology
  • Liver / drug effects*
  • Plant Stems / chemistry*
  • Pyranocoumarins / chemistry
  • Pyranocoumarins / isolation & purification*
  • Pyranocoumarins / pharmacology*

Substances

  • Alkaloids
  • Pyranocoumarins
  • Galactosamine