RNA editing in cancer: Mechanistic, prognostic, and therapeutic implications

Mol Cell Oncol. 2015 Dec 14;3(2):e1117702. doi: 10.1080/23723556.2015.1117702. eCollection 2016 Mar.

Abstract

We have recently provided a comprehensive analysis of A-to-I RNA editing events in various cancer types, revealing many clinically relevant RNA editing sites and demonstrating that RNA editing can selectively affect cancer drug sensitivity. Our results unveil mechanistic, prognostic, and therapeutic implications for RNA editing in cancer.

Keywords: Driver events; RNA editing; drug sensitivity; pancancer analysis; prognostic marker.