Chemoselective Synthesis of Carbamates using CO2 as Carbon Source

ChemSusChem. 2016 Aug 9;9(15):1916-20. doi: 10.1002/cssc.201600521. Epub 2016 Jul 4.

Abstract

Synthesis of carbamates directly from amines using CO2 as the carbon source is a straightforward and sustainable approach. Herein, we describe a highly effective and chemoselective methodology for the synthesis of carbamates at room temperature and atmospheric pressure. This methodology can also be applied to protect the amino group in amino acids and peptides, and also to synthesize important pharmaceuticals.

Keywords: carbamates; carbon dioxide; chemoselective; peptides; protecting group.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Atmospheric Pressure
  • Carbamates / chemical synthesis*
  • Carbamates / chemistry
  • Carbon / chemistry*
  • Carbon Dioxide / chemistry*
  • Chemistry Techniques, Synthetic
  • Temperature

Substances

  • Amino Acids
  • Carbamates
  • Carbon Dioxide
  • Carbon