Prevalence and risk factors associated with the patency of ductus arteriosus in premature neonates: a prospective observational study from Iran

J Matern Fetal Neonatal Med. 2017 Jun;30(12):1460-1464. doi: 10.1080/14767058.2016.1219991. Epub 2016 Aug 25.

Abstract

Background: Patent ductus arteriosus (PDA) is a common problem in the preterm infants. The frequency of PDA varies with the time of study, and the characteristics of the population included in the trial.

Aims and objective: To determine the prevalence and prenatal risk factor associated with PDA.

Methods and material: This prospective cross-sectional observational study was carried out on neonates who had gestational age below 37 weeks during the period of February 2014 to September 2014. Echocardiography was done at 4-7 days of postnatal age. The association between prenatal risk factors of the infants and the PDA was studied.

Results: From a total population of 200 enrolled infants 22.5% had PDA. The mean gestational age and birth weight were 32.1 ± 2.65 (weeks) and 1741 ± 622.85 (g), respectively. Maternal antepartum hemorrhage, respiratory distress syndrome (RDS), need for surfactant, birth weights, female gender, gestational age, Apgar scores at 1 and 5 min of the infants were found to be associated with the prevalence of PDA.

Conclusion: Several prenatal factors make preterm newborns susceptible to PDA. These risk factors should be identified as soon as possible for early commencement of PDA management.

Keywords: Patent ductus arteriosus; preterm neonates; prevalence.

Publication types

  • Observational Study

MeSH terms

  • Birth Weight / physiology*
  • Cross-Sectional Studies
  • Delivery, Obstetric / statistics & numerical data
  • Ductus Arteriosus, Patent / epidemiology*
  • Ductus Arteriosus, Patent / etiology
  • Echocardiography
  • Female
  • Gestational Age*
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Pregnancy
  • Prevalence
  • Prospective Studies
  • Respiratory Distress Syndrome, Newborn / complications
  • Respiratory Distress Syndrome, Newborn / drug therapy
  • Risk Factors