Siderophores as molecular tools in medical and environmental applications

Org Biomol Chem. 2016 Sep 21;14(35):8212-27. doi: 10.1039/c6ob01400c. Epub 2016 Aug 5.

Abstract

Almost all life forms depend on iron as an essential micronutrient that is needed for electron transport and metabolic processes. Siderophores are low-molecular-weight iron chelators that safeguard the supply of this important metal to bacteria, fungi and graminaceous plants. Although animals and the majority of plants do not utilise siderophores and have alternative means of iron acquisition, siderophores have found important clinical and agricultural applications. In this review, we will highlight the different uses of these iron-chelating molecules.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Bacteria / metabolism
  • Biodegradation, Environmental
  • Chelation Therapy / methods
  • Drug Carriers
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / metabolism
  • Enzyme Inhibitors / pharmacology
  • Fungi / metabolism
  • Iron Chelating Agents / chemistry*
  • Iron Chelating Agents / metabolism*
  • Iron Chelating Agents / pharmacology
  • Plants / metabolism
  • Siderophores / chemistry*
  • Siderophores / metabolism*
  • Siderophores / pharmacology
  • Surface Properties

Substances

  • Anti-Bacterial Agents
  • Drug Carriers
  • Enzyme Inhibitors
  • Iron Chelating Agents
  • Siderophores