Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage

Xiaolei Cai; Aishwarya Bandla; Duo Mao; Guangxue Feng; Wei Qin; Lun-De Liao; Nitish Thakor; Ben Zhong Tang; Bin Liu

doi:10.1002/adma.201601191

Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage

Adv Mater. 2016 Oct;28(39):8760-8765. doi: 10.1002/adma.201601191. Epub 2016 Aug 11.

Authors

Xiaolei Cai^{1

2}, Aishwarya Bandla^{3

4}, Duo Mao¹, Guangxue Feng¹, Wei Qin⁵, Lun-De Liao^{6

7}, Nitish Thakor^{3

4}, Ben Zhong Tang⁵, Bin Liu^{8

9}

Affiliations

¹ Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585.
² NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, #05-01, Singapore, 117456.
³ Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, Singapore, 117456.
⁴ Department of Biomedical Engineering, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077.
⁵ Department of Chemistry and Division of Biomedical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077.
⁶ Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, Singapore, 117456. ldliao@nhri.org.tw.
⁷ Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan. ldliao@nhri.org.tw.
⁸ Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585. cheliub@nus.edu.sg.
⁹ Institute of Materials Research and Engineering, 2 Fusionopolis Way, Innovis, #08-03, Singapore, 138634. cheliub@nus.edu.sg.

PMID: 27511643
DOI: 10.1002/adma.201601191

Abstract

Detection of damage to the blood-brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompatibility, and aggregation-induced emission characteristics offer high detection specificity to detect BBB damage via a photothrombotic ischemia rat model.

Keywords: aggregation-induced emission; blood-brain barrier damage; nanoparticles; photothrombotic ischemia; stroke.

MeSH terms

Animals
Biocompatible Materials
Biological Transport
Blood-Brain Barrier
Brain Ischemia
Coloring Agents
Nanoparticles*
Rats

Substances

Biocompatible Materials
Coloring Agents