Leptin and Hormones: Energy Homeostasis

Georgios A Triantafyllou; Stavroula A Paschou; Christos S Mantzoros

doi:10.1016/j.ecl.2016.04.012

Leptin and Hormones: Energy Homeostasis

Endocrinol Metab Clin North Am. 2016 Sep;45(3):633-45. doi: 10.1016/j.ecl.2016.04.012.

Authors

Georgios A Triantafyllou¹, Stavroula A Paschou¹, Christos S Mantzoros²

Affiliations

¹ Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST 820, Boston, MA 02215, USA.
² Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST 820, Boston, MA 02215, USA. Electronic address: cmantzor@bidmc.harvard.edu.

PMID: 27519135
DOI: 10.1016/j.ecl.2016.04.012

Abstract

Leptin, a 167 amino acid adipokine, plays a major role in human energy homeostasis. Its actions are mediated through binding to leptin receptor and activating JAK-STAT3 signal transduction pathway. It is expressed mainly in adipocytes, and its circulating levels reflect the body's energy stores in adipose tissue. Recombinant methionyl human leptin has been FDA approved for patients with generalized non-HIV lipodystrophy and for compassionate use in subjects with congenital leptin deficiency. The purpose of this review is to outline the role of leptin in energy homeostasis, as well as its interaction with other hormones.

Keywords: Energy homeostasis; Hormonal interactions; Leptin; Metabolism; Obesity.

Publication types

Review

MeSH terms

Adipocytes
Energy Metabolism*
Homeostasis*
Humans
Leptin / physiology*

Substances

Leptin