Treatment of HEV Infection in Patients with a Solid-Organ Transplant and Chronic Hepatitis

Nassim Kamar; Sébastien Lhomme; Florence Abravanel; Olivier Marion; Jean-Marie Peron; Laurent Alric; Jacques Izopet

doi:10.3390/v8080222

Treatment of HEV Infection in Patients with a Solid-Organ Transplant and Chronic Hepatitis

Viruses. 2016 Aug 15;8(8):222. doi: 10.3390/v8080222.

Authors

Nassim Kamar^{1

2

3}, Sébastien Lhomme^{4

5

6}, Florence Abravanel^{7

8

9}, Olivier Marion^{10

11}, Jean-Marie Peron^{12

13}, Laurent Alric^{14

15

16}, Jacques Izopet^{17

18

19}

Affiliations

¹ Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse 31059, France. kamar.n@chu-toulouse.fr.
² INSERM U1043, IFR-BMT, CHU Purpan, Toulouse 31000, France. kamar.n@chu-toulouse.fr.
³ University Toulouse III-Paul Sabatier, Toulouse 31000, France. kamar.n@chu-toulouse.fr.
⁴ INSERM U1043, IFR-BMT, CHU Purpan, Toulouse 31000, France. lhomme.s@chu-toulouse.fr.
⁵ University Toulouse III-Paul Sabatier, Toulouse 31000, France. lhomme.s@chu-toulouse.fr.
⁶ Laboratory of Virology, CHU Purpan, Toulouse 31000, France. lhomme.s@chu-toulouse.fr.
⁷ INSERM U1043, IFR-BMT, CHU Purpan, Toulouse 31000, France. abravanel.f@chu-toulouse.fr.
⁸ University Toulouse III-Paul Sabatier, Toulouse 31000, France. abravanel.f@chu-toulouse.fr.
⁹ Laboratory of Virology, CHU Purpan, Toulouse 31000, France. abravanel.f@chu-toulouse.fr.
¹⁰ Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse 31059, France. marion-olivier@hotmail.fr.
¹¹ INSERM U1043, IFR-BMT, CHU Purpan, Toulouse 31000, France. marion-olivier@hotmail.fr.
¹² University Toulouse III-Paul Sabatier, Toulouse 31000, France. peron.jm@chu-toulouse.fr.
¹³ Department of Hepatology, CHU Purpan, Toulouse 31000, France. peron.jm@chu-toulouse.fr.
¹⁴ University Toulouse III-Paul Sabatier, Toulouse 31000, France. alric.l@chu-toulouse.fr.
¹⁵ MR 152 IRD-Toulouse III University, Toulouse 31000, France. alric.l@chu-toulouse.fr.
¹⁶ Internal Medicine-Digestive Department, CHU Purpan, Toulouse, 31000, France. alric.l@chu-toulouse.fr.
¹⁷ INSERM U1043, IFR-BMT, CHU Purpan, Toulouse 31000, France. izopet.j@chu-toulouse.fr.
¹⁸ University Toulouse III-Paul Sabatier, Toulouse 31000, France. izopet.j@chu-toulouse.fr.
¹⁹ Laboratory of Virology, CHU Purpan, Toulouse 31000, France. izopet.j@chu-toulouse.fr.

Abstract

Hepatitis E virus (HEV) infection can cause hepatic and extra-hepatic manifestations. Treatment of HEV infection has been thoroughly studied in solid-organ-transplant patients who have developed a chronic HEV infection. In this review, we report on our current knowledge regarding treatment of HEV infection.

Keywords: hepatitis E; immunosuppressants; interferon; ribavirin; sustained virological response.

Publication types

Review

MeSH terms

Hepatitis E / drug therapy*
Hepatitis, Chronic / drug therapy*
Humans
Interferons / therapeutic use*
Organ Transplantation / adverse effects*
Ribavirin / therapeutic use*
Transplant Recipients*

Substances

Ribavirin
Interferons