Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors

Small GTPases. 2018 May 4;9(3):203-215. doi: 10.1080/21541248.2016.1218407. Epub 2016 Aug 22.

Abstract

The 20 members of the Rho GTPase family are key regulators of a wide-variety of biological activities. In response to activation, they signal via downstream effector proteins to induce dynamic alterations in the organization of the actomyosin cytoskeleton. In this review, post-translational modifications, mechanisms of dysregulation identified in human pathological conditions, and the ways that Rho GTPases might be targeted for chemotherapy will be discussed.

Keywords: CDC42; GTPase; Rac; Rho; actin; mutation; phosphorylation; signal transduction; ubiquitin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease / genetics*
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Mutation*
  • Protein Processing, Post-Translational*
  • Ubiquitination
  • rho GTP-Binding Proteins / antagonists & inhibitors
  • rho GTP-Binding Proteins / chemistry
  • rho GTP-Binding Proteins / genetics*
  • rho GTP-Binding Proteins / metabolism*

Substances

  • Enzyme Inhibitors
  • rho GTP-Binding Proteins