Abstract
A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.
Keywords:
Aspergillus fumigatus; TR46/Y121F/T289A; azole resistance; environment; invasive aspergillosis.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
MeSH terms
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Aged
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use*
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Arthritis, Rheumatoid / complications
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Arthritis, Rheumatoid / drug therapy
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Aspergillosis / drug therapy*
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Aspergillosis / etiology*
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Aspergillus fumigatus / drug effects*
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Aspergillus fumigatus / genetics
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Azoles / pharmacology
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Azoles / therapeutic use*
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Cytochrome P-450 Enzyme System / genetics
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Drug Resistance, Fungal*
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Fatal Outcome
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Fungal Proteins / genetics
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Humans
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Immunocompromised Host*
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Infliximab / adverse effects
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Infliximab / therapeutic use
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Microbial Sensitivity Tests
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Mutation
Substances
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Antifungal Agents
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Azoles
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Fungal Proteins
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Cytochrome P-450 Enzyme System
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Infliximab
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cytochrome P-450 CYP51A, Aspergillus