Abstract
The synthesis of a series of thiolated paclitaxel analogs is described as part of a novel nanomedicine program aimed at developing formulations of paclitaxel that will bind to gold nanoparticles for tumor targeted drug delivery. Preliminary evaluation of the new nanomedicine composed of 27 nm gold nanoparticles, tumor necrosis factor alpha (TNFα), thiolated polyethylene glycol (PEG-thiol), and one of several thiolated paclitaxel analogs is presented.
MeSH terms
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Animals
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Buffers
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Cell Line, Tumor
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Chemistry Techniques, Synthetic
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Drug Carriers / chemical synthesis*
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Drug Carriers / chemistry*
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Drug Liberation
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Gold / chemistry*
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Humans
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Metal Nanoparticles / chemistry*
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Mice
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Models, Molecular
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Paclitaxel / chemistry*
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Paclitaxel / pharmacokinetics
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Paclitaxel / pharmacology*
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Polyethylene Glycols / chemistry
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Protein Conformation
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Tumor Necrosis Factor-alpha / chemistry
Substances
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Buffers
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Drug Carriers
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Tumor Necrosis Factor-alpha
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Polyethylene Glycols
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Gold
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Paclitaxel