Abstract
Small interfering RNA (siRNA) delivered from reactive oxygen species-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2, thereby increasing the expression of progrowth genes and increasing vasculature, proliferating cells, and tissue development in diabetic wounds.
Keywords:
diabetes; reactive oxygen species; scaffolds; siRNA; wound healing.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
MeSH terms
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Animals
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Cell Proliferation / drug effects
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Diabetes Mellitus / drug therapy*
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Hypoxia-Inducible Factor-Proline Dioxygenases
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Male
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Neovascularization, Physiologic / drug effects
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Procollagen-Proline Dioxygenase / administration & dosage*
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Procollagen-Proline Dioxygenase / genetics*
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RNA, Small Interfering / administration & dosage*
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RNA, Small Interfering / genetics*
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Rats
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Rats, Sprague-Dawley
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Reactive Oxygen Species / metabolism*
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Tissue Engineering / methods
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Tissue Scaffolds / chemistry
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Wound Healing / drug effects*
Substances
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RNA, Small Interfering
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Reactive Oxygen Species
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Procollagen-Proline Dioxygenase
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Egln1 protein, rat
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Hypoxia-Inducible Factor-Proline Dioxygenases