Abstract
Glycosylated 4-amino-1,8-naphthalimide derivatives possess a native glycosidic linkage that can be selectively hydrolysed in situ by glycosidase enzymes to release the naphthalimide as a fluorescent imaging or therapeutic agent. In vitro studies using a variety of cancer cell lines demonstrated that the naphthalimides only get taken up into cells upon enzymatic cleavage from the glycan unit; a mechanism that offers a novel approach for the targeted delivery of probes/drugs.
MeSH terms
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1-Naphthylamine / analogs & derivatives*
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1-Naphthylamine / chemistry
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1-Naphthylamine / metabolism
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Cell Line, Tumor
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / metabolism*
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Glycoside Hydrolases / metabolism*
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Glycosylation
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HeLa Cells
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Humans
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Molecular Imaging / methods*
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Naphthalimides / chemistry*
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Naphthalimides / metabolism*
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Quinolones / chemistry*
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Quinolones / metabolism*
Substances
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Fluorescent Dyes
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Naphthalimides
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Quinolones
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4-amino-1,8-naphthalimide
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1-Naphthylamine
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Glycoside Hydrolases