Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53

Stephen Bohlman; James J Manfredi

doi:10.1016/j.ccell.2016.09.017

Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53

Cancer Cell. 2016 Oct 10;30(4):513-514. doi: 10.1016/j.ccell.2016.09.017.

Authors

Stephen Bohlman¹, James J Manfredi²

Affiliations

¹ Department of Oncological Sciences and The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
² Department of Oncological Sciences and The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: james.manfredi@mssm.edu.

PMID: 27728801
DOI: 10.1016/j.ccell.2016.09.017

Abstract

In this issue of Cancer Cell, Gu et al. characterize small molecules that inhibit the interaction of Mdm2 with the mRNA that encodes the anti-apoptotic XIAP, simultaneously decreasing expression of both proteins. This represents a novel approach that has relevance in tumor cells independent of p53 status.

Publication types

Comment

MeSH terms

Apoptosis
Humans
Nuclear Proteins / genetics
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins c-mdm2 / genetics
RNA*
RNA, Messenger / genetics
Tumor Suppressor Protein p53 / genetics*

Substances

Nuclear Proteins
Proto-Oncogene Proteins
RNA, Messenger
Tumor Suppressor Protein p53
RNA
Proto-Oncogene Proteins c-mdm2