Abstract
Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu2-XTe) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / administration & dosage*
-
Breast Neoplasms / drug therapy*
-
Cell Line, Tumor
-
Contrast Media / administration & dosage
-
Copper / administration & dosage
-
Drug Carriers / administration & dosage*
-
Drug Resistance, Multiple*
-
Drug Therapy, Combination / methods*
-
Female
-
Humans
-
Hyperthermia, Induced / methods
-
Models, Biological
-
Nanostructures / administration & dosage*
-
Photoacoustic Techniques
-
Photochemotherapy / methods
-
Photosensitizing Agents
-
Tellurium / administration & dosage
-
Theranostic Nanomedicine
-
X-Rays
Substances
-
Antineoplastic Agents
-
Contrast Media
-
Drug Carriers
-
Photosensitizing Agents
-
Copper
-
tellurous acid
-
Tellurium