LSMO Nanoparticles Coated by Hyaluronic Acid for Magnetic Hyperthermia

Yuanwei Chen; Ying Wang; Xi Liu; Mai Lu; Jiangwei Cao; Tao Wang

doi:10.1186/s11671-016-1756-3

LSMO Nanoparticles Coated by Hyaluronic Acid for Magnetic Hyperthermia

Nanoscale Res Lett. 2016 Dec;11(1):538. doi: 10.1186/s11671-016-1756-3. Epub 2016 Dec 3.

Authors

Yuanwei Chen¹, Ying Wang², Xi Liu³, Mai Lu³, Jiangwei Cao¹, Tao Wang⁴

Affiliations

¹ Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou, 730000, China.
² Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou, 730000, China. yingw@lzu.edu.cn.
³ Key Laboratory of Opto-Electronic Technology and Intelligent Control, Ministry of Education, Lanzhou Jiaotong University, Lanzhou, 730070, China.
⁴ Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou, 730000, China. wtao@lzu.edu.cn.

Abstract

Magnetic hyperthermia with the treating temperature range of 41-46 °C is an alternative therapy for cancer treatment. In this article, lanthanum strontium manganates (La_1-x Sr _x MnO₃, 0.25 ≤ × ≤ 0.35) magnetic nanoparticles coated by hyaluronic acid (HA) which possesses the ability of targeting tumor cells were prepared by a simple hydrothermal method combined with a high-energy ball milling technique. The crystal structure, morphology, magnetic properties of the HA-coated magnetic nanoparticles (MNPs), and their heating ability under alternating magnetic field were investigated. It was found the HA-coated La_0.7Sr_0.3MnO₃, with particle diameter of ~100 nm, Curie temperature of 45 °C at a concentration 6 mg/ml, gave the optimal induction heating results. The heating temperature saturates at 45.7 °C, and the ESAR is 5.7 × 10^-3 W/g · kHz · (kA/m²) which is much higher than other reported results.

Keywords: Functionalization; Hyaluronic acid; LSMO; Magnetic hyperthermia.