In Vitro Antifungal Susceptibility Profiles of 12 Antifungal Drugs against 55 Trichophyton schoenleinii Isolates from Tinea Capitis Favosa Patients in Iran, Turkey, and China

Shuwen Deng; Saham Ansari; Macit Ilkit; Haleh Rafati; Mohammad T Hedayati; Mojtaba Taghizadeh-Armaki; Ayatollah Nasrollahi-Omran; Ali Tolooe; Ping Zhan; Wanqing Liao; Henrich A van der Lee; Paul E Verweij; Seyedmojtaba Seyedmousavi

doi:10.1128/AAC.01753-16

In Vitro Antifungal Susceptibility Profiles of 12 Antifungal Drugs against 55 Trichophyton schoenleinii Isolates from Tinea Capitis Favosa Patients in Iran, Turkey, and China

Antimicrob Agents Chemother. 2017 Jan 24;61(2):e01753-16. doi: 10.1128/AAC.01753-16. Print 2017 Feb.

Authors

Shuwen Deng^{1

2}, Saham Ansari³, Macit Ilkit⁴, Haleh Rafati⁵, Mohammad T Hedayati^{6

7}, Mojtaba Taghizadeh-Armaki^{6

7}, Ayatollah Nasrollahi-Omran⁸, Ali Tolooe⁹, Ping Zhan¹⁰, Wanqing Liao^{1

2}, Henrich A van der Lee¹¹, Paul E Verweij¹¹, Seyedmojtaba Seyedmousavi^{12

11}

Affiliations

¹ Shanghai Key Laboratory of Molecular Medical Mycology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
² First Hospital of Xinjiang Medical University, Xinjiang, China.
³ Department of Medical Mycology and Parasitology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey.
⁵ Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands.
⁶ Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
⁷ Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
⁸ Department of Medical Mycology, Faculty of Medicine, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran.
⁹ Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
¹⁰ Dermatology Hospital of Jiangxi Province, Jiangxi Provincial Institute of Dermatology, Nanchang, China.
¹¹ Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
¹² Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran Seyedmousavi@nih.gov.

Abstract

Trichophyton schoenleinii is an anthropophilic dermatophyte mainly causing tinea favosa of the scalp in certain regions of the world, especially Africa and Asia. We investigated the in vitro susceptibilities of 55 T. schoenleinii isolates collected over the last 30 years from Iran, Turkey, and China to 12 antifungals using the CLSI broth microdilution method. Our results revealed that terbinafine and ketoconazole were the most potent antifungal agents among those tested, independently of the geographic regions where strains were isolated.

Keywords: Trichophyton schoenleinii; antifungal susceptibility testing; tinea capitis favosa.

MeSH terms

Antifungal Agents / pharmacology*
China
Humans
Iran
Ketoconazole / pharmacology
Microbial Sensitivity Tests
Naphthalenes / pharmacology
Terbinafine
Tinea Favosa / microbiology*
Trichophyton / drug effects*
Trichophyton / isolation & purification
Turkey

Substances

Antifungal Agents
Naphthalenes
Terbinafine
Ketoconazole