Abstract
Prebiotics improve the growth or activities of specific microbial genera and species in the gut microbiota in order to confer health benefits to the host. In this study, we investigated the effect of poly-gamma-glutamate (γ-PGA) as a prebiotic on the gut microbiota of mice and the organ distributions of γ-PGA in mice. Pyrosequencing analysis for 16S rRNA genes of bacteria indicated that oral administration of γ-PGA increased the abundance of Lactobacillales while reducing the abundance of Clostridiales in murine guts. It is suggested that oral administration of γ-PGA can be helpful for modulating the gut microbiota as a prebiotic.
Keywords:
Poly-γ-glutamate; gut microbiota; organ distributions; prebiotics.
MeSH terms
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Administration, Oral
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Animals
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Bacteria / classification
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Bacteria / genetics
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Bacteria / isolation & purification*
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Bacterial Load
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Clostridiales / growth & development
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Clostridiales / isolation & purification
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Colon / chemistry
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Colon / microbiology
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Feces / microbiology
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Gastrointestinal Microbiome*
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Gastrointestinal Tract / chemistry
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Gastrointestinal Tract / microbiology
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High-Throughput Nucleotide Sequencing
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Lactobacillales / genetics
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Lactobacillales / isolation & purification
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Mice
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Polyglutamic Acid / administration & dosage
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Polyglutamic Acid / analogs & derivatives*
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Polyglutamic Acid / pharmacokinetics
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Prebiotics* / analysis
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RNA, Ribosomal, 16S
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Tissue Distribution
Substances
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Prebiotics
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RNA, Ribosomal, 16S
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poly(gamma-glutamic acid)
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Polyglutamic Acid