Biofilm mitigation by drug (gentamicin)-loaded liposomes promoted by pulsed ultrasound

Dong Ma; Junru Wu

doi:10.1121/1.4972336

Biofilm mitigation by drug (gentamicin)-loaded liposomes promoted by pulsed ultrasound

J Acoust Soc Am. 2016 Dec;140(6):EL534. doi: 10.1121/1.4972336.

Authors

Dong Ma¹, Junru Wu¹

Affiliation

¹ Department of Physics, and Materials Science Program, University of Vermont, Burlington, Vermont 05405, USA dma@uvm.edu, jwu@uvm.edu.

PMID: 28039994
DOI: 10.1121/1.4972336

Abstract

The gentamicin-loaded nano-sized liposomes are shown to penetrate into alginate-based Ralstonia insidiosa bacterial biofilms by acoustic streaming generated by moderate pulsed ultrasound (frequency = 2.25 MHz, 10% duty cycle and spatially and temporally averaged intensity, I_SATA ≈ 4.4 W/cm²). The liposomes are then burst by the scanned relatively high intensity ultrasound (frequency = 1.1 MHz, 10% duty cycle, the spatially and temporally averaged intensity I_SATA ≈ 90 W/cm²) in situ, and the gentamicin solution is released from the liposomes resulting in 72% of Ralstonia insidiosa killing.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biofilms*
Gentamicins
Liposomes
Ralstonia
Ultrasonic Waves

Substances

Gentamicins
Liposomes