Validation of a quantitative method to measure neural respiratory drive in children during sleep

Sandra Ya-Chu Chuang; Arthur Teng; Jane Elizabeth Butler; Simon Charles Gandevia; Hiran Selvadurai; Adam Jaffe

doi:10.1016/j.resp.2017.02.004

Validation of a quantitative method to measure neural respiratory drive in children during sleep

Respir Physiol Neurobiol. 2017 May:239:75-80. doi: 10.1016/j.resp.2017.02.004. Epub 2017 Feb 14.

Authors

Sandra Ya-Chu Chuang¹, Arthur Teng², Jane Elizabeth Butler³, Simon Charles Gandevia³, Hiran Selvadurai⁴, Adam Jaffe⁵

Affiliations

¹ Respiratory Department, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia; School of Women's and Children's Health, University of New South Wales, Level 8, The Bright Alliance Building, Cnr of Avoca & High Streets, Randwick, NSW 2031, Australia. Electronic address: sandra.chuang@unsw.edu.au.
² School of Women's and Children's Health, University of New South Wales, Level 8, The Bright Alliance Building, Cnr of Avoca & High Streets, Randwick, NSW 2031, Australia; Sleep Medicine Department, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia.
³ Neuroscience Research Australia, Barker St, Randwick, NSW 2031, Australia; School of Medical Sciences, Wallace Wurth Building, University of New South Wales, Kensington, NSW 2052, Australia.
⁴ Respiratory Department, Children's Hospital Westmead, Corner Hawkesbury Road and Hainsworth Street, Westmead, NSW 2145, Australia.
⁵ Respiratory Department, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia; School of Women's and Children's Health, University of New South Wales, Level 8, The Bright Alliance Building, Cnr of Avoca & High Streets, Randwick, NSW 2031, Australia.

PMID: 28213200
DOI: 10.1016/j.resp.2017.02.004

Abstract

Aims: Quantitatively measure and validate analysis of neural respiratory drive (NRD) using a commercial polysomnography system in children during sleep.

Method: Surface electromyogram of the diaphragm (sEMGdi) recorded from primary snoring children were analysed. A subset was re-analysed to assess intra- and inter-investigator reproducibility. Effects of different band pass filter settings (20-100Hz vs 10-1000Hz) on sEMGdi amplitude were evaluated.

Results: Mean sEMGdi from 45 children aged 4.38 years (median; IQR 3.00-7.96) was 5.05μV (SD 2.73). The sEMGdi had a high intra-subject intraclass correlation coefficient (ICC) of 0.88. sEMGdi analysis was reproducible with high ICC between occasions (0.99; 95% CI 0.98-0.99) and between investigators (0.98; 95% CI 0.97-0.99). There was also a high ICC (0.99, 95% CI 0.96-1.00) between the sEMGdi measured using different band-pass filter settings. Age and BMI were negative predictors of sEMGdi (p<0.0001 and p=0.0004 respectively).

Conclusion: NRD in children during sleep as assessed by sEMGdi can be quantified in a reliable and reproducible fashion.

Keywords: Child; Diaphragm EMG; Physiology; Polysomnography; Reproducibility; Sleep.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child
Child, Preschool
Diaphragm / physiology*
Electromyography
Evoked Potentials, Motor / physiology
Female
Humans
Male
Polysomnography
Reproducibility of Results
Respiration*
Sleep / physiology*