Abstract
Two new rearranged linear angucycline glycosides, designated grincamycins G and H (1 and 2), together with three known congers P-1894B (vineomycin A1, 3), saquayamycin B (4) and vineomycin B2 (5), were obtained from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of 1 and 2 were elucidated by MS, 1D and 2D NMR techniques. Compounds 2-5 showed significant inhibitory effect on Jurkat T-cell proliferation with IC50 values of 3.0, 0.011, 0.037 and 0.3 μM, respectively.
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification*
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Anthraquinones / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cell Proliferation / drug effects
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Humans
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Inhibitory Concentration 50
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Jurkat Cells
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Leukemia, T-Cell / drug therapy
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Leukemia, T-Cell / pathology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Streptomyces / chemistry
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Streptomyces / metabolism*
Substances
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Anthraquinones
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Antineoplastic Agents
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Glycosides