Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas

Brittany C Parker Kerrigan; Yuzaburo Shimizu; Michael Andreeff; Frederick F Lang

doi:10.1016/j.jcyt.2017.02.002

Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas

Cytotherapy. 2017 Apr;19(4):445-457. doi: 10.1016/j.jcyt.2017.02.002. Epub 2017 Feb 21.

Authors

Brittany C Parker Kerrigan¹, Yuzaburo Shimizu², Michael Andreeff³, Frederick F Lang⁴

Affiliations

¹ Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; The Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Bioengineering, Rice University, Houston, Texas, USA.
² Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; The Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan.
³ Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
⁴ Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; The Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address: flang@mdanderson.org.

Abstract

Mesenchymal stromal cells (MSCs) are a type of adult stem cell that has been exploited for the treatment of a variety of diseases, including cancer. In particular, MSCs have been studied extensively for their ability to treat glioblastoma (GBM), the most common and deadly form of brain cancer in adults. MSCs are attractive therapeutics because they can be obtained relatively easily from patients, are capable of being expanded numerically in vitro, can be easily engineered and are inherently capable of homing to tumors, making them ideal vehicles for delivering biological antitumoral agents. Oncolytic viruses are promising biological therapeutic agents that have been used in the treatment of GBMs, and MSCs are currently being explored as a means of delivering these viruses. Here we review the role of MSCs in the treatment of GBMs, focusing on the intersection of MSCs and oncolytic viruses.

Keywords: adenovirus; gliomas; mesenchymal stem cell; mesenchymal stromal cell.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / therapeutic use
Brain Neoplasms / therapy*
Cell Line, Tumor
Glioblastoma / therapy
Glioma / therapy*
Humans
Mesenchymal Stem Cell Transplantation / methods*
Mesenchymal Stem Cells / metabolism
Mesenchymal Stem Cells / virology*
Oncolytic Virotherapy / methods*
Oncolytic Viruses / metabolism*

Substances

Antineoplastic Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding