A GO-Se nanocomposite as an antioxidant nanozyme for cytoprotection

Yanyan Huang; Chaoqun Liu; Fang Pu; Zhen Liu; Jinsong Ren; Xiaogang Qu

doi:10.1039/c7cc00045f

A GO-Se nanocomposite as an antioxidant nanozyme for cytoprotection

Chem Commun (Camb). 2017 Mar 9;53(21):3082-3085. doi: 10.1039/c7cc00045f.

Authors

Yanyan Huang¹, Chaoqun Liu¹, Fang Pu², Zhen Liu², Jinsong Ren², Xiaogang Qu²

Affiliations

¹ Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing 100039, China.
² Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.

PMID: 28243649
DOI: 10.1039/c7cc00045f

Abstract

GO-Se nanocomposites are fabricated with excellent glutathione peroxidase (GPx)-like properties to protect cells against oxidative stress. Compared with SeNPs, the GO-Se nanozymes exhibit higher GPx-mimic catalytic efficiency. Cell experiments further confirm their excellent cytoprotection capacity.

MeSH terms

Animals
Antioxidants / chemistry
Antioxidants / pharmacology*
Catalysis
Cell Survival / drug effects
Dose-Response Relationship, Drug
Graphite / chemistry
Graphite / pharmacology*
Mice
Nanocomposites / chemistry*
Oxidative Stress / drug effects
Oxides / chemistry
Oxides / pharmacology*
Particle Size
RAW 264.7 Cells
Selenium / chemistry
Selenium / pharmacology*
Structure-Activity Relationship
Surface Properties

Substances

Antioxidants
Oxides
Graphite
Selenium