Symmetry assisted tuning of bending and brittle multi-component forms of probenecid

U B Rao Khandavilli; Balakrishna R Bhogala; Anita R Maguire; Simon E Lawrence

doi:10.1039/c7cc01091e

Symmetry assisted tuning of bending and brittle multi-component forms of probenecid

Chem Commun (Camb). 2017 Mar 16;53(23):3381-3384. doi: 10.1039/c7cc01091e.

Authors

U B Rao Khandavilli¹, Balakrishna R Bhogala¹, Anita R Maguire², Simon E Lawrence¹

Affiliations

¹ Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Ireland. simon.lawrence@ucc.ie.
² Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork, Ireland.

PMID: 28265636
DOI: 10.1039/c7cc01091e

Abstract

The mechanical flexibility known in the antihyperuricemia drug probenecid has been extended into multi-component systems using co-formers with two donor or acceptor sites, in contrast to systems with a single H-bond acceptor that exhibit brittle behaviour. The piperazinium salt demonstrates that GRAS co-formers can be used to maintain mechanical flexibility with drug molecules.