Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery

PLoS Med. 2017 Mar 14;14(3):e1002256. doi: 10.1371/journal.pmed.1002256. eCollection 2017 Mar.

Abstract

In a Perspective, David Bennett makes a case for neural reserve to be considered as a therapeutic endpoint in clinical trials for dementia.

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Brain / physiology*
  • Cognitive Reserve*
  • Dementia / drug therapy*
  • Drug Discovery*
  • Humans