DNA footprinting with hydroxyl radical

Nature. 1988 Apr 14;332(6165):663-4. doi: 10.1038/332663a0.

Abstract

High resolution images of proteins bound to DNA can be achieved through the use of a simple inorganic chemical system that produces the hydroxyl radical.

MeSH terms

  • Binding Sites
  • Chemical Phenomena
  • Chemistry
  • DNA / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Edetic Acid
  • Ferrous Compounds
  • Hydroxides*
  • Hydroxyl Radical
  • Transcription Factor TFIIIA
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • Ferrous Compounds
  • Hydroxides
  • Transcription Factor TFIIIA
  • Transcription Factors
  • Fe(II)-EDTA
  • Hydroxyl Radical
  • DNA
  • Edetic Acid