Physiologically Based Pharmacokinetic Modeling of Drug Transporters to Facilitate Individualized Dose Prediction

Aleksandra Galetin; Ping Zhao; Shiew-Mei Huang

doi:10.1016/j.xphs.2017.03.036

Physiologically Based Pharmacokinetic Modeling of Drug Transporters to Facilitate Individualized Dose Prediction

J Pharm Sci. 2017 Sep;106(9):2204-2208. doi: 10.1016/j.xphs.2017.03.036. Epub 2017 Apr 5.

Authors

Aleksandra Galetin¹, Ping Zhao², Shiew-Mei Huang²

Affiliations

¹ Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993. Electronic address: Aleksandra.Galetin@manchester.ac.uk.
² Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993.

PMID: 28390843
DOI: 10.1016/j.xphs.2017.03.036

Abstract

Physiologically based pharmacokinetic modeling is a commonly used strategy in the drug development and regulatory submissions. This commentary provides a critical overview of the current status of physiologically based pharmacokinetic methodologies to predict transporter-mediated pharmacokinetics, in addition to the impact of disease and genetics with respect to local and systemic concentration.

Keywords: pharmacokinetic/pharmacodynamic models; transporters.

Publication types

Review
Research Support, U.S. Gov't, P.H.S.
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biological Transport / physiology*
Humans
Models, Biological
Pharmaceutical Preparations / administration & dosage*
Pharmaceutical Preparations / metabolism*
Pharmacokinetics
Precision Medicine / methods

Substances

Pharmaceutical Preparations