Abstract
Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.
MeSH terms
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Anticarcinogenic Agents / chemistry
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Anticarcinogenic Agents / pharmacology*
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / pathology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Female
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Humans
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Isothiocyanates / chemistry
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Isothiocyanates / pharmacology*
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MCF-7 Cells
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Molecular Structure
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Proteomics*
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Structure-Activity Relationship
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Sulfoxides
Substances
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Anticarcinogenic Agents
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Isothiocyanates
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Sulfoxides
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sulforaphane