Fatty acid transporting proteins: Roles in brain development, aging, and stroke

Prostaglandins Leukot Essent Fatty Acids. 2018 Sep:136:35-45. doi: 10.1016/j.plefa.2017.04.004. Epub 2017 Apr 21.

Abstract

Polyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain-containing protein (Mfsd2a) play critical roles in the uptake of various fatty acids, especially polyunsaturated fatty acids. They are not only involved in neurodevelopment, but also have great impact on neurological disease, such as aging related dementia and stroke.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Aging / metabolism*
  • Animals
  • Brain / growth & development*
  • Brain / metabolism
  • Fatty Acid Transport Proteins / metabolism*
  • Fatty Acids, Unsaturated / metabolism
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Stroke / metabolism*

Substances

  • Fatty Acid Transport Proteins
  • Fatty Acids, Unsaturated