Neural Manifolds for the Control of Movement

Juan A Gallego; Matthew G Perich; Lee E Miller; Sara A Solla

doi:10.1016/j.neuron.2017.05.025

Neural Manifolds for the Control of Movement

Neuron. 2017 Jun 7;94(5):978-984. doi: 10.1016/j.neuron.2017.05.025.

Authors

Juan A Gallego¹, Matthew G Perich², Lee E Miller³, Sara A Solla⁴

Affiliations

¹ Department of Physiology, Northwestern University, Chicago, IL 60611, USA; Neural and Cognitive Engineering Group, Centre for Robotics and Automation CSIC-UPM, Arganda del Rey 28500, Spain.
² Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
³ Department of Physiology, Northwestern University, Chicago, IL 60611, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL 60611, USA.
⁴ Department of Physiology, Northwestern University, Chicago, IL 60611, USA; Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208, USA. Electronic address: solla@northwestern.edu.

Abstract

The analysis of neural dynamics in several brain cortices has consistently uncovered low-dimensional manifolds that capture a significant fraction of neural variability. These neural manifolds are spanned by specific patterns of correlated neural activity, the "neural modes." We discuss a model for neural control of movement in which the time-dependent activation of these neural modes is the generator of motor behavior. This manifold-based view of motor cortex may lead to a better understanding of how the brain controls movement.

Publication types

Review

MeSH terms

Animals
Brain / physiology
Humans
Models, Neurological
Motor Cortex / physiology*
Movement / physiology*
Neurons / physiology*

Abstract

Publication types

MeSH terms

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