Mammalian synthetic biology in the age of genome editing and personalized medicine

Patrick Ho; Yvonne Y Chen

doi:10.1016/j.cbpa.2017.06.003

Mammalian synthetic biology in the age of genome editing and personalized medicine

Curr Opin Chem Biol. 2017 Oct:40:57-64. doi: 10.1016/j.cbpa.2017.06.003. Epub 2017 Jun 16.

Authors

Patrick Ho¹, Yvonne Y Chen²

Affiliations

¹ Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, 420 Westwood Plaza, Boelter Hall 5531, Los Angeles, CA 90095, USA.
² Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, 420 Westwood Plaza, Boelter Hall 5531, Los Angeles, CA 90095, USA. Electronic address: yvonne.chen@ucla.edu.

Abstract

The recent expansion of molecular tool kits has propelled synthetic biology toward the design of increasingly sophisticated mammalian systems. Specifically, advances in genome editing, protein engineering, and circuitry design have enabled the programming of cells for diverse applications, including regenerative medicine and cancer immunotherapy. The ease with which molecular and cellular interactions can be harnessed promises to yield novel approaches to elucidate genetic interactions, program cellular functions, and design therapeutic interventions. Here, we review recent advancements in the development of enabling technologies and the practical applications of mammalian synthetic biology.

Publication types

Review

MeSH terms

Animals
CRISPR-Cas Systems
Cell- and Tissue-Based Therapy / methods
Gene Editing / methods*
Gene Expression Regulation
Gene Regulatory Networks
Genetic Engineering / methods
Humans
Immunotherapy / methods
Precision Medicine / methods*
Synthetic Biology / methods*

Abstract

Publication types

MeSH terms

Grants and funding