Biomimetic composite scaffolds based on surface modification of polydopamine on electrospun poly(lactic acid)/cellulose nanofibrils

Zhangqiang Yang; Junhui Si; Zhixiang Cui; Jianhua Ye; Xiaofeng Wang; Qianting Wang; Kaiping Peng; Wenzhe Chen; Shia-Chung Chen

doi:10.1016/j.carbpol.2017.07.010

Biomimetic composite scaffolds based on surface modification of polydopamine on electrospun poly(lactic acid)/cellulose nanofibrils

Carbohydr Polym. 2017 Oct 15:174:750-759. doi: 10.1016/j.carbpol.2017.07.010. Epub 2017 Jul 13.

Authors

Zhangqiang Yang¹, Junhui Si², Zhixiang Cui³, Jianhua Ye¹, Xiaofeng Wang⁴, Qianting Wang², Kaiping Peng⁵, Wenzhe Chen⁶, Shia-Chung Chen⁷

Affiliations

¹ School of Materials Science and Engineering, Fuzhou University, Fujian, 350000, China.
² School of Materials Science and Engineering, Fujian University of Technology, Fujian, 350118, China; Fujian Provincial Key Laboratory of Advanced Materials Processing and Application, Fujian, 350118, China.
³ School of Materials Science and Engineering, Fuzhou University, Fujian, 350000, China; School of Materials Science and Engineering, Fujian University of Technology, Fujian, 350118, China; Fujian Provincial Key Laboratory of Advanced Materials Processing and Application, Fujian, 350118, China. Electronic address: cuizhixiang2006@126.com.
⁴ National Center for International Research of Micro-Nano Molding Technology & Key Laboratory for Micro Molding Technology of Henan Province, Zhengzhou University, Henan, 450001, China.
⁵ School of Materials Science and Engineering, Fuzhou University, Fujian, 350000, China. Electronic address: pkp715@163.com.
⁶ School of Materials Science and Engineering, Fuzhou University, Fujian, 350000, China; School of Materials Science and Engineering, Fujian University of Technology, Fujian, 350118, China; Fujian Provincial Key Laboratory of Advanced Materials Processing and Application, Fujian, 350118, China.
⁷ Department of Mechanical Engineering, Chung Yuan Christian University, Chung-Li, 32023, Taiwan.

PMID: 28821128
DOI: 10.1016/j.carbpol.2017.07.010

Abstract

An appropriate surface chemical property is crucial in tissue engineering scaffolds, which promotes cell attachment and proliferation. A biomimetic composite scaffold with a polydopamine (PDA) coating layer on electrospun poly(lactic acid) (PLA)/cellulose nanofibrils (CNF) composite nanofiber was developed in this study. PLA/CNF composite nanofibers were fabricated and then coated via treatment with a dopamine solution. The PDA coating layer was successfully formed on the surface of the PLA/CNF composite nanofiber by using a simple, environment-friendly, and effective procedure. Results indicated that the addition of CNF into the PLA matrix can effectively improve the deposition rate of the PDA coating layer on the surface of the composite nanofiber during the initial stage of coating because of hydrogen bonding between the CNF and PDA molecular chains. The hydrophilicity and mechanical properties of the PLA/CNF-PDA scaffold were higher than those of the PLA/CNF scaffold. In addition, the cell culture test showed that the adhesion, proliferation, and growth of human mesenchymal stem cells (hMSCs) cultured on the PLA/CNF-PDA scaffold were significantly enhanced relative to those cultured on the PLA/CNF scaffold because of the introduction of the PDA coating. This finding suggested that surface biofunctionalization via the PDA coating layer could simply and effectively enhance cell biocompatibility for polymer-based scaffolds.

Keywords: Cellulose nanofibrils (CNF); Electrospinning; Poly(lactic acid) (PLA); Surface modification.