Abstract
We evaluated the in vitro and in vivo effects of nikkomycin Z combined with an echinocandin (anidulafungin or micafungin) against two Candida albicans isolates and their lab-derived echinocandin-resistant fks mutants with FKS1 S645Y and FKS1 S645P. Synergistic effects were observed in all tested strains (fractional inhibitory concentration index, <0.5). Enhanced survival was observed in an immunocompromised murine model (log-rank test, P < 0.02). Our study demonstrated the therapeutic potential of nikkomycin Z-echinocandin combinations in managing echinocandin resistance.
Keywords:
Candida albicans; FKS; echinocandin; nikkomycin Z.
Copyright © 2017 Cheung and Hui.
MeSH terms
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Aminoglycosides / pharmacology*
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Anidulafungin
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Animals
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Antifungal Agents / pharmacology*
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Candida albicans / drug effects*
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Candida albicans / genetics
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Candida albicans / isolation & purification
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Candidiasis / drug therapy*
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Candidiasis / microbiology
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Chitin Synthase / antagonists & inhibitors
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Drug Combinations
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Drug Resistance, Fungal / genetics
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Drug Synergism
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Echinocandins / pharmacology*
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Glucosyltransferases / genetics
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Humans
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Lipopeptides / pharmacology*
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Micafungin
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Mice
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Mice, Inbred ICR
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Microbial Sensitivity Tests
Substances
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Aminoglycosides
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Antifungal Agents
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Drug Combinations
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Echinocandins
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Lipopeptides
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Anidulafungin
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nikkomycin
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Glucosyltransferases
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Chitin Synthase
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Micafungin