Synthesis of Spirobidihydropyrazole through Double 1,3-Dipolar Cycloaddition of Nitrilimines with Allenoates

Org Lett. 2017 Sep 15;19(18):4714-4717. doi: 10.1021/acs.orglett.7b01961. Epub 2017 Aug 31.

Abstract

The double 1,3-dipolar cycloaddition of allenoates with nitrilimines has been achieved under mild reaction conditions, affording a variety of spirobidihydropyrazoles in moderate to excellent yields with excellent diastereoselectivities. The reaction diastereoselectively constructs double dihydropyrazole moieties and two chiral centers including a spiro carbon center.

Publication types

  • Research Support, Non-U.S. Gov't