Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity

Trisha Basu; Seyedmojtaba Seyedmousavi; Janyce A Sugui; Nariman Balenga; Ming Zhao; Kyung Joo Kwon Chung; Sabrina Biardel; Michel Laviolette; Kirk M Druey

doi:10.1016/j.jaci.2017.07.034

Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity

J Allergy Clin Immunol. 2018 Jan;141(1):423-425.e7. doi: 10.1016/j.jaci.2017.07.034. Epub 2017 Sep 4.

Authors

Trisha Basu¹, Seyedmojtaba Seyedmousavi², Janyce A Sugui², Nariman Balenga¹, Ming Zhao³, Kyung Joo Kwon Chung², Sabrina Biardel⁴, Michel Laviolette⁴, Kirk M Druey⁵

Affiliations

¹ Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH), Bethesda, Md.
² Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH), Bethesda, Md.
³ Protein Chemistry, Research Technologies Branch, NIAID/NIH, Rockville, Md.
⁴ Institut Universitaire de Cardiologie et Pneumologie de Quebec (Laval University), Departement Multidisciplinaire de Pneumologie et de Chirurgie Thoracique de l'IUCPQ, Quebec City, Quebec, Canada.
⁵ Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH), Bethesda, Md. Electronic address: kdruey@niaid.nih.gov.

Abstract

A fungal protease (Alp1/Asp f13) from Aspergillus fumigatus was detected in the airways of subjects with asthma but not controls, which correlated strongly with disease severity, respiratory dysfunction, and steroid use.

Publication types

Letter
Research Support, N.I.H., Intramural

MeSH terms

Allergens / immunology
Aspergillus fumigatus / enzymology
Aspergillus fumigatus / immunology*
Asthma / diagnosis*
Asthma / immunology*
Bacterial Proteins / immunology*
Endopeptidases / immunology*
Humans
Respiratory Mucosa / immunology
Respiratory Mucosa / microbiology
Respiratory Mucosa / pathology
Severity of Illness Index

Substances

Allergens
Bacterial Proteins
Endopeptidases
alkaline protease

Grants and funding

Z01 AI000939-04/Intramural NIH HHS/United States