Crowd Control: E7 Conservation Is the Key to Cancer

Elizabeth A White; Karl Munger

doi:10.1016/j.cell.2017.08.033

Crowd Control: E7 Conservation Is the Key to Cancer

Cell. 2017 Sep 7;170(6):1057-1059. doi: 10.1016/j.cell.2017.08.033.

Authors

Elizabeth A White¹, Karl Munger²

Affiliations

¹ Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104, USA. Electronic address: eawhite@mail.med.upenn.edu.
² Department of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA. Electronic address: karl.munger@tufts.edu.

PMID: 28886377
DOI: 10.1016/j.cell.2017.08.033

Abstract

Several human papillomavirus type 16 (HPV16) oncoproteins contribute to cellular transformation in vitro. In this issue of Cell, Mirabello and colleagues use high-throughput sequencing data to assess the diversity of HPV16 isolates from human patients. These data suggest that the E7 oncoprotein is the fundamental contributor to in vivo carcinogenesis.

Publication types

Comment

MeSH terms

Human papillomavirus 16*
Humans
Neoplasms
Oncogene Proteins, Viral*
Papillomavirus E7 Proteins
Repressor Proteins

Substances

Oncogene Proteins, Viral
Papillomavirus E7 Proteins
Repressor Proteins

Grants and funding

R01 CA066980/CA/NCI NIH HHS/United States