Compassionate Use of Bacteriophage Therapy for Foot Ulcer Treatment as an Effective Step for Moving Toward Clinical Trials

Randolph Fish; Elizabeth Kutter; Gordon Wheat; Bob Blasdel; Mzia Kutateladze; Sarah Kuhl

doi:10.1007/978-1-4939-7395-8_14

Compassionate Use of Bacteriophage Therapy for Foot Ulcer Treatment as an Effective Step for Moving Toward Clinical Trials

Methods Mol Biol. 2018:1693:159-170. doi: 10.1007/978-1-4939-7395-8_14.

Authors

Randolph Fish^{1

2}, Elizabeth Kutter^{3

4}, Gordon Wheat^{3

5}, Bob Blasdel⁶, Mzia Kutateladze⁷, Sarah Kuhl^{8

9}

Affiliations

¹ PhageBiotics Research Foundation, Gray's Harbor Community Hospital, Aberdeen, WA, USA. rcfish4@gmail.com.
² Wound Centers at St Joseph's Medical Center, Tacoma, WA, USA. rcfish4@gmail.com.
³ PhageBiotics Research Foundation, Gray's Harbor Community Hospital, Aberdeen, WA, USA.
⁴ Bacteriophage Lab - The Evergreen State College, Evergreen Parkway NW, Olympia, WA, 98505, USA.
⁵ Kaiser Permanente Northwest, Saint Peter Hospital Family Medicine Residency, 3324 Sunset Beach Dr., Olympia, WA, 98502, USA.
⁶ Laboratory of Gene Technology, KU Leuven, Kasteelpark Arenberg, 21, Belgium.
⁷ George Eliava Institute of Bacteriophages, Microbiology and Virology - 3, Gotua str., Tbilisi, 0160, GA, USA.
⁸ VA Northern California, Muir Road, Martinez, CA, 94553, USA.
⁹ University of California, San Francisco, CA, USA.

PMID: 29119440
DOI: 10.1007/978-1-4939-7395-8_14

Abstract

We here present detailed descriptions of successful treatment of a series of diabetic toe ulcers using the Eliava BioPreparations' commercial preparation of the very well-studied anti-staphylococcal bacteriophage Sb-1. This chapter outlines what we feel is an appropriate mechanism to speed movement toward full-scale clinical trials with bacteriophage use to treat wound infections and to help address the crisis in antibiotic resistance.

Keywords: Amputation; Bacteriophage therapy; Debridement; Diabetic foot ulcers; Osteomyelitis.

MeSH terms

Bacterial Infections / complications*
Bacterial Infections / microbiology
Bacterial Physiological Phenomena
Bacteriophages*
Foot Ulcer / etiology
Foot Ulcer / therapy*
Humans
Phage Therapy*