Ketogenic diet and anorexia nervosa

Med Hypotheses. 2017 Nov:109:150-152. doi: 10.1016/j.mehy.2017.10.011. Epub 2017 Oct 13.

Abstract

This hypothesis suggest that starvation-induced ketosis, which leads to a fundamental biochemical change in the metabolic fuel supply of the brain, is uniquely anxiolytic and rewarding to patients prone to AN. Ketosis can easily be replicated by a unique diet marked by high fat, moderate protein, and very low carbohydrate. This diet, known as a ketogenic diet (KGD) mimics starvation, thus allowing the patient to experience the anxiolytic state of ketosis, and yet avoid the morbidity of starvation.

MeSH terms

  • Adolescent
  • Animals
  • Anorexia Nervosa / diet therapy*
  • Anorexia Nervosa / psychology
  • Appetite*
  • Brain / metabolism*
  • Diet, Ketogenic*
  • Dietary Carbohydrates / administration & dosage
  • Dietary Fats / administration & dosage
  • Feeding Behavior
  • Female
  • Humans
  • Ketosis
  • Male
  • Models, Theoretical
  • Young Adult

Substances

  • Dietary Carbohydrates
  • Dietary Fats